Welcome to the Purugganan Laboratory at the Center for Genomics and Systems Biology at New York University. Research in the laboratory is focused on evolutionary, ecological and functional genomics of plants. Active projects in the lab include (1) the Environmental Gene Regulatory Interaction Network (EGRINs) project which aims to characterize gene regulatory networks involved in the rice stress response. (2) There are also multiple active QTL mapping projects in the lab which aim to identify genes controlling variability in salt tolerance among rice varieties. (3) A third major line of research is characterization of the molecular basis of natural variation in Arabidopsis flowering time. (4) Finally, we have an ongoing interest in the process of plant domestication and are currently using whole genome sequencing to understand the origin and diversification of date palm (Phoenix dactylifera) and rice.
The work in the laboratory is funded by the National Science Foundation, the NYUAD Research Institute, and the Zegar Family Foundation
Selected Recent PublicationsChoi J.Y., Platts A.E., Fuller D.Q., Hsing Y.L., Wing R.A., Purugganan M.D. 2017. The Rice Paradox: Multiple origins but single domestication in Asian Rice. Mol. Biol. Evol. 34(4):969-979.
Yuan W., Flowers J.M., Sahraie D.J., Purugganan M.D. 2016. Cryptic genetic variation for Arabidopsis thaliana seed germination speed in a novel salt stress environment. G3. doi: 10.1534/g3.116.033944
Meyer R.S., Choi J.Y., Sanches M., Plessis A., Flowers J.M., Amas J., Dorph K., Barretto A., Gross B., Fuller D.Q., Kofi Bimpong I., Ndjiondjop M-N., Hazzouri K.M., Gregorio G.B., Purugganan M.D. 2016. Domestication history and geographical adaptation inferred from a SNP map of African rice. Nat. Genet. doi:10.1038/ng.3633
Yuan W., Flowers J.M., Sahraie D.J., Ehrenreich I. M., Purugganan M.D. 2016. Extreme QTL mapping of germination speed in Arabidopsis thaliana. Mol. Ecol. doi: 10.1534/g3.116.033944
Joly-Lopez Z., Flowers J.M., Purugganan M.D. 2016. Developing maps of fitness consequences for plant genomes. 2016. Curr. Op. Plant Biol. 30:101-107.
Plessis A., Hafemeister C., Wilkins O., Gonzaga ZJ, Meyer RS, Pires I et al. 2015. Multiple abiotic stimuli are integrated in the regulation of rice gene expression under field conditions. Elife. Nov 26;4. pii: e08411. doi: 10.7554/eLife.08411
Hazzouri K.M., Flowers, J.M., Visser H.J., Khierallah H.S.M., Rosas, U. et al. 2015. Whole genome re-sequencing of date palms yields insights into diversification of a fruit tree crop. Nat. Commun. 6:8824 doi:10.1038/ncomms9824
Flowers J.M., Hazzouri K.M., Pham G.M., Rosas U., Bahmani T. et al. 2015. Whole genome resequencing reveals extensive natural variation in the model green alga Chlamydomonas reinhardtii. 2015. Plant Cell. 27:2353-2369. doi:10.1105/tpc.15.00492
Rosas U., Mei Y., Xie Q., Banta J.A., Zhou R.W., Seufferheld G., Gerard S., Chou L., Bhambhra N, Parks J.D., Flowers J.M., McClung C.R., Hanzawa Y., Purugganan M.D. 2014. Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS. Nature Communications 5:3651, doi: 10.1038/ncomms4651
Meyer RS, Purugganan MD. (2013) Evolution of crop species: genetics of domestication and diversification. Nat Rev Genet. 2013 Dec;14(12):840-52. doi: 10.1038/nrg3605
Molina J., Hazzouri K. M., Nickrent D., Geisler M., Meyer R. S., Pentony M. M., Flowers J. M. Pelser P., Barcelona J., Inovejas S. A. Uy I., Yuan W., Wilkins O., Michel C.I., LockLear S., Concepcion G. P. Purugganan M. D. 2014. Possible Loss of the Chloroplast Genome in the Parasitic Flowering Plant Rafflesia lagascae (Rafflesiaceae). Mol. Biol. Evol. 31:793-803
The main laboratory is located on the 6th floor of the Center for Genomics and Systems Biology, at 12 Waverly Place in the historic neighborhood of Greenwich Village in New York City three blocks east of Washington Square ParkThe nearest subway stops are 8th St. [ N, Q, R, W ] and West 4th St. [A, C, E, B, D, F, V ].
You can find a map of our location here: Map
The lab has recently expanded to New York University, Abu Dhabi, in the United Arab Emirates. The expansion is part of the new Center for Genomics and Systems Biology in the Experimental Research Building at NYUAD, Saadiyat Island, Abu Dhabi. The lab is staffed full time by a research associate, Khaled Hazzouri, and a technician, Sylvie Ferrand
We regularly have open positions for graduate students and post-doctoral researchers in the lab. Please contact us.
Send correspondence by mail to:Department of Biology
1009 Main Building
100 Washington Square East
New York University, New York, NY 10003-6688
office: (212) 992-9628
lab: (212) 998-8465
fax: (212) 995-4015